AOP Wiki KER Challenge
AI-extracted Key Event Relationships XML
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KER: Disruption of sodium channel gating kinetics → Decreased oligodendrocyte differentiation
Upstream:
KE1977
Downstream:
KE2116
WoE: Low-to-Moderate
Explores how altered VGSC gating in neurons and OPCs impairs activity-dependent signalling required for maturation.
KER: Decreased oligodendrocyte differentiation → Hypomyelination
Upstream:
KE2116
Downstream:
KE2107
WoE: High
A direct mechanistic link where the failure of OPCs to mature results in an obligatory reduction of CNS myelin.